WebBrian H. Shirts, in Managing Health in the Genomic Era, 2024. Hereditary non-polyposis colorectal cancer (HNPCC, aka Lynch syndrome) also involves variants in genes necessary for DNA repair ... BRCA2, and their protein partners, carry out repair of double-stranded DNA damage. The progression to cancer initiated by mismatch repair failure is ... WebJun 18, 2024 · BRCA1 and BRCA2 are tumor suppressor genes, meaning when they function normally their job is to keep tumors from forming. Some people however, have an altered or mutated copy of the gene and …
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