Mitochondria play a central role in maintaining the life cycle of retinal ganglion cells because of their high energy dependence. Mitochondria are made within the central somata of the retinal ganglion cell, transported down axons, and distributed where they are needed. Genetic mutations in mitochondrial DNA, vitamin depletion, alcohol and tobacco abuse, and use of certain drugs can cause derangements in efficient transport of mitochondria, which can cause a primary or secon… Optic atrophy refers to the death of the retinal ganglion cell axons that comprise the optic nerve with the resulting picture of a pale optic nerve on fundoscopy. Optic atrophy is an end stage that arises from myriad causes of optic nerve damage anywhere along the path from the retina to the lateral geniculate. … See more Since the optic nerve is the conduit for information from the retina to the brain, a damaged optic nerve will result in vision loss. Subtle damage might not affect … See more The management goal is to intervene before optic atrophy is noted or to save remaining function. This will depend on the underlying cause for the optic nerve … See more
Toxic and nutritional optic neuropathy - Wikipedia
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Optic Nerve Hypoplasia - American Academy of Ophthalmology
WebJun 25, 2013 · The atrophic phase may demonstrate retrochiasmatic tissue loss with reduction of grey matter volume in the primary visual cortex and reduced white matter volume in the optic chiasm, optic tract, and optic … WebThe optic disc is the area around the optic nerve where the nerve enters the eye. In cases of optic atrophy, the optic disc will become pale due to a lack of blood flow. If your... WebAug 8, 2024 · Optic atrophy is the end stage of a disease process affecting the retinogeniculate portion of the visual pathway, characterized by a non-specific sign of optic disc pallor. While the peripheral nervous system has an intrinsic ability for repair and regeneration, the central nervous system, for the most part, is incapable of such processes. northern mn map highway